职称/职务

副教授,副院长

研究方向

药物化学生物学

邮箱

xinyahan@ahut.edu.cn;xinyah@126.com

学习工作经历

2016.6-至今：bat365官网登录，我院化学生物学与制药工程系，讲师、副教授

2010.9-2016.6：华中师范大学，化学学院，有机化学专业，理学博士

2006.9-2010.6：青岛农业大学，化学与药学院，制药工程专业，工学学士

主要科研项目及成果

博士生导师，省级青年拔尖人才，安徽省高校杰出青年科研项目获得者，安徽省优秀青年研究生导师，bat365官网登录青年学者（A档）。主要从事药物化学生物学与生物材料研究，先后主持国家重点研发计划政府间国际科技创新合作重点专项任务、国家自然科学基金青年项目等国家级项目4项、安徽省高校杰出青年科研项目、安徽省重点研究与开发计划项目等省部级项目4项；负责科技部发展中国家杰出青年科学家来华工作计划2项；以第一作者或通讯作者在Org. Lett., Sensor Actuat. B-CHEM.Eur. J. Med. Chem.等国际知名期刊发表高质量论文26篇，授权国家发明专利8项；获安徽省教学成果奖特等奖、一等奖、三等奖各1项，主持省级课程思政示范课1门、省级研究生国际学术论坛1项。

近期主持的部分科研项目：

1国家重点研发计划政府间国际科技创新合作重点专项任务，2017YFE0118200，2019.1-2022.12，108万，已结题，主持

2国家自然基金委国际(地区)合作与交流项目任务，32061143045，2021.01-2023.12，50万，在研，主持

3国家自然科学基金青年项目，82104065，2022.01-2024.12，30万，在研，主持

4安徽省高校杰出青年科研项目，2022AH020035，2022.12-2025.11，100万，在研，主持

5科技部中国--匈牙利科技合作交流项目，2018-II-2，2020.1-2021.12，10万，在研，主持

6科技部中国--乌克兰科技合作交流项目，CU03-04，2020.1-2021.12，8万，在研，主持

7安徽省重点研究与开发计划项目，201904b11020025，2019.1-2021.12，30万，已结题，主持

8安徽省自然基金面上项目，1908085MB35，2019.7-2022.6，10万，已结题，主持

9科技部发展中国家杰出青年科学家来华工作计划，越南-18-001，2019.1-2019.12，15万，已结题，负责人

10安徽省高等学校自然科学研究项目（重点项目），KJ2018A0040，2018.1-2019.12，6万，已结题，主持

11微生物技术国家重点实验室开放课题，M2017-11，2017.10-2019.9，10万，已结题，主持

12农药与化学生物学教育部重点实验室开放课题，201801A02，2019.1-2021.12，9万，已结题，主持

13理论有机化学与功能分子教育部重点实验室开放课题，LKF1401，2017.1-2018.12，1.5万，已结题，主持

14bat365官网登录校青年基金项目，QZ201609，2017.1-2018.12，0.8万，已结题，主持

15bat365官网登录人才引进科研启动经费，10万，在研，主持

近期发表的部分论文:

1)Qian Chen, Jiaxu Liu, Shenjun Liu, Jian Zhang, Lifang He, Renyong Liu, Hui Jiang,Xiaya Han*and Kui Zhang*, Visual and Rapid Detection of Nerve Agent Mimics in Gas and Solution Phase by a Simple Fluorescent Probe,Anal. Chem. 2023,95: 4390-4394.

2)Xinya Han, Qinfei Xia, Qi Wang, Xiaolong Ding, Qinghe Gao , Yiliang Chen, Jiaxu Liu, Jufen Yan, Qi Sun*, Qian Chen*, and Kui Zhang, A highly selective and sensitive hydrogen sulfide scavenger along with its imaging in cells and zebrafish,Sensor Actuat. B-CHEM.,2023,379:133169.

3) Qinghe Gao*,Zhenhua Sun, Manman Wu, Yimei Guo,Xinya Han*, Jufen Yan, Minh Ngoc Ha, Quynh Mai Le and Yongtao Xu*, Di-tert-butyl peroxide as an effective two-carbon unit in oxidative radical cyclization toward 7-methylazolo[1,5-a]pyrimidines,Org. Chem. Front.2022, 9, 3050.

4)Huan Qin, Xiaolong Ding, Shi-Qi Cheng, Siyong Qin*,Xinya Han*, Yue Sun*, Yi Liu, A H₂S-regulated artificial nanochannel fabricated by supramolecular coordination strategy,J. Phys. Chem. Lett., 2022, 13, 9232-9237.

5)Qinghe Gao^#,Zhenhua Sun^#,Qinfei Xia^#,Ruonan Li, Wenlong Wang, Siwei Ma, Yixin Chai,Manman Wu, Wei Hu, Péter Ábrányi-Balogh, György M. Keserű, andXinya Han*,Vinylation of α‑Aminoazoles with Triethylamine: A General Strategyto Construct Azolo[1,5-a]pyrimidines with a NonsubstitutedEthylidene Fragment,Org. Lett.2021, 23, 2664−2669.

6) Qian Chen, Yudie Sun, Shengjun Liu, Jian Zhang, Cheng Zhang, Hui Jiang,Xinya Han*,Lifang He, Suhua Wang, Kui Zhang*,Colorimetric and fluorescent sensors for detection of nerve agents andorganophosphorus pesticides,Sensor Actuat. B-CHEM.,2021,344:130278.

7)Xinya Han,Yunyuan Huang,Lin Wei,Haifeng Chen,Yanrong Guo,Zilong Tang,Wei Hu,Qinfei Xia,Qi Wang,Jufen Yan*,Yanliang Ren*,Biological evaluation and SAR analysis of novel covalent inhibitors against fructose-1,6-bisphosphatase,Bioorg. Med. Chem.2020,28: 115624.

8) Qi Sun^#, Yuan Qiu^#, Jun Chen, Fengshou Wu, Xiaogang Luo, Yanrong Guo,Xinya Han*, Dawei Wang*,A colorimetric and fluorescence turn-on probe for the detection ofpalladium in aqueous solution and its applicationin vitroandin vivo,Spectrochim. Acta Part A2020,239,118547.

9) Ling Jin, Li Zhang, Lei Yang, Xingrong Wua, Cheng Zhang, Kang Wei, Lifang He,Xinya Han*, Hongbin Qiao*, Abdullah M. Asiri, Khalid A. Alamry,andKui Zhang*,Orange-Red, Green, and Blue Fluorescence Carbon Dots for White Light Emitting Diodes,J.Mater.Sci.Technol.2020, 50, 184-191.

10)Jun Tang, Yali Cao, Fei Ruan, Fengfeng Li, Yangxin Jin, Minh Ngoc Ha,Xinya Han*, and Qingping Ke*,New Approach for Controllable Synthesis of N-MnOx Micro-flowers and Their Superior Catalytic Performance for Benzoxazole Synthesis,Ind. Eng. Chem. Res.2020, 59, 9408-9413.

11) Zilong Song, Yun Zhu,Jingrui LiuShukeGuo,YuchengGu,Xinya Han*,Hongqiang Dong, Qi Sun, Weihua Zhang*,Mingzhi Zhang*, Diversity-oriented synthesis and antifungal activities of novel pimprinine derivative bearing a 1,3,4-oxadiazole-5-thioether moiety,Mol.Divers.2020,https://doi.org/10.1007/s11030-020-10048-8

12) Yunyuan Huang^#, Lin Wei^#,Xinya Han^#, Haifeng Chen^#, Yanliang Ren*,Yanhong Xu, Rongrong Song, Li Rao, Chen Su, Chao Peng, Lingling Feng, Jian Wan*, Discovery of novel allosteric site and covalent inhibitors of FBPase with potent hypoglycemic effects,Eur.J.Med.Chem.2019, 184(15), 111749-11762.

13) Qinghe Gao*^,#,Xinya Han^#,Peiyuan Tong, Zhiang Zhang, Haotian Shen, YanrongGuo, Suping Bai, Aerobic α,β-C(sp3)-H Bond Difunctionalization and C-N BondCleavage of Triethylamine: Difunctional Ammonium Iodide Enablingthe Regioselective Synthesis of 4-Arylpyrimido[1,2-b]indazoles,Org. Lett.2019, 21 (15), 6074-6078.

14)Xinya Han^#, Xiuyun Zhu^#,Zongqin Hong^#, Lin We, Yanliang Ren*, Fen Wan, Shuaihua Zhu, Hao Peng, Li Guo, Li Rao, Lingling Feng, and Jian Wan*, Structure-Based Rational Design of Novel Inhibitors Against Fructose-1,6-Bisphosphate Aldolase from Candida albicans,J. Chem. Inf. Model.2017, 57 (6), 1426-1438.

15)Xinya Han^#,Yunyuan Huang^#,Rui Zhang^#, Shan Xiao, Shuaihua Zhu, Nian Qin, Zongqin Hong, Lin Wei, Jiangtao Feng, Yanliang Ren, Lingling Feng*, and Jian Wan*, New Insight into the Binding Modes of TNP-AMP to the Human Liver Fructose-1,6-bisphosphatase,Spectrochim. Acta Part A2016, 165 (5), 155-160.

16)Xinya Han^#,Xiuyun Zhu^#,Shuaihua Zhu^#, Lin Wei, Li Rao, Zongqin Hong, Li Guo, Haifeng Chen, Bo Chi, Yan Liu, Lingling Feng, Yanliang Ren*, and Jian Wan*, A Rational Design, Synthesis, Biological Evaluation and Structure−Activity Relationship Study of Novel Inhibitors against Cyanobacterial Fructose-1,6-bisphosphate Aldolase,J. Chem. Inf. Model.2016, 56 (1), 73-81.

17)Haifeng Chen^#,Xinya Han^#,Nian Qin^#, Lin Wei, Yue Yang, Li Rao, Bo Chi, Lingling Feng, Yanliang Ren,* and Jian Wan* Synthesis and Biological Evaluation of β-Nitrostyrene Derivatives as Antifungal Agents Against Magnaporthegrisea,Bioorg. Med. Chem.2016, 24 (6), 1225-1230.

18) Ding Li^#,Xinya Han^#, QidongTu^#, Lingling Feng, Di Wu, Yao Sun, Haifeng Chen, Yongjian Li, Yanliang Ren,* and Jian Wan*,Structure-Based Design and Synthesis of Novel Dual-TargetInhibitors Against Cyanobacterial Fructose-1,6-Bisphosphate Aldolase and Fructose-1,6- Bisphosphatase,J. Agric. Food Chem.2013, 61 (31), 7453-7461.